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Article

Regulation of N-glycosylation and secretion of Isthmin-1 by its C-mannosylation.

Biochimica et biophysica acta. General subjects - 1 Mar 2021

Yoshimoto Satoshi, Katayama Kazuhiro, Suzuki Takehiro, Dohmae Naoshi, Simizu Siro

Abstract excerpt

BACKGROUND: C-mannosylation is a type of protein glycosylation. Human Isthmin-1 (ISM1) is a 52-kDa secreted protein with a thrombospondin type 1 repeat (TSR) domain, containing two consensus C-mannosylation sequences at Trp223 and Trp226. In this study, we sought to examine the role of C-mannosylation in the secretion of ISM1. METHODS: We established and cultured an ISM1-overexpressing HT1080 cell line and...

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PMID: 33412225
DOI: 10.1016/j.bbagen.2020.129840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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