Article
Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation.
Molecular biology of the cell - 1 Feb 2020
Graham Jill B, Sunryd Johan C, Mathavan Ketan, Weir Emma, Larsen Ida Signe Bohse, Halim Adnan, Clausen Henrik, Cousin Hélène, Alfandari Dominque, Hebert Daniel N
Abstract excerpt
Protein glycosylation plays essential roles in protein structure, stability, and activity such as cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose glycans at conserved sites and it was recently demonstrated that the transmembrane and tetratricopeptide repeat-containing proteins 1-4 (TMTC1-4) gene products contribute to the addition of these O-linked mannoses. Here, biochemical,...
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