Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diversity of Mechanisms Underlying Latent TGF-β Activation in Recessive Dystrophic Epidermolysis Bullosa.

The Journal of investigative dermatology - 1 Jun 2021

Akasaka Eijiro, Kleiser Svenja, Sengle Gerhard, Bruckner-Tuderman Leena, Nyström Alexander

Abstract excerpt

Injury- and inflammation-driven progressive dermal fibrosis is a severe manifestation of recessive dystrophic epidermolysis bullosa-a genetic skin blistering disease caused by mutations in COL7A1. TGF-β activation plays a prominent part in progressing dermal fibrosis. However, the underlying mechanisms are not fully elucidated. TGF-β is secreted in a latent form, which has to be activated for its biological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type VII
Share to Epidermolysis Bullosa Dystrophica

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrosis

Share to Healthy Volunteers

Share to Matrix Metalloproteinases

Share to Reactive Oxygen Species

Share to Thrombospondin 1

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 33333127
DOI: 10.1016/j.jid.2020.10.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diversity of Mechanisms Underlying Latent TGF-β Activation in Recessive Dystrophic Epidermolysis Bullosa.PMID 33333127Read ↗

Impaired Wound Healing, Fibrosis, and Cancer: The Paradigm of Recessive Dystrophic Epidermolysis Bullosa.Semantic proximity Read ↗

Pro‐inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang‐(1‐7)Semantic proximity Read ↗

Pathomechanisms of Altered Wound Healing in Recessive Dystrophic Epidermolysis Bullosa.Semantic proximity Read ↗

Injury- and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosaSemantic proximity Read ↗

Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditionsSemantic proximity Read ↗

Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-β signalling in modifying disease severity.Semantic proximity Read ↗

Cellular and molecular mechanisms in fibrosisSemantic proximity Read ↗

Alterations in the microenvironment of junctional epidermolysis bullosa keratinocytes: A gene expression studySemantic proximity Read ↗

Dermal fibroblast subsets and their roles in inflammatory and autoimmune skin diseasesSemantic proximity Read ↗

LTBPs, more than just an escort service.Semantic proximity Read ↗

Mechanistic interrogation of mutation-independent disease modulators of RDEB identifies the small leucine-rich proteoglycan PRELP as a TGF-β antagonist and inhibitor of fibrosis.Semantic proximity Read ↗

Systemic Collagen VII Replacement Therapy for Advanced Recessive Dystrophic Epidermolysis BullosaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.