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Article

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.

Disease models & mechanisms - 19 Feb 2021

Vaughan Danielle, Mitchell Robert, Kretz Oliver, Chambers David, Lalowski Maciej, Amthor Helge, Ritvos Olli, Pasternack Arja, Matsakas Antonios, Vaiyapuri Sakthivel, Huber Tobias B, Denecke Bernd, Mukherjee Abir, Widera Darius, Patel Ketan

Abstract excerpt

Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have been successfully developed to attenuate the signalling properties of these molecules, which result in augmenting muscle growth. However, these molecules, in particular activin, play major roles in tissue homeostasis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33408083
DOI: 10.1242/dmm.047555
PMCID: PMC7903914

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