Article
Retinal Imaging Findings in Carriers With PSEN1-Associated Early-Onset Familial Alzheimer Disease Before Onset of Cognitive Symptoms.
JAMA ophthalmology - 1 Jan 2021
Armstrong Grayson W, Kim Leo A, Vingopoulos Filippos, Park Jea Young, Garg Itika, Kasetty Megan, Silverman Rebecca F, Zeng Rebecca, Douglas Vivian Paraskevi, Lopera Francisco, Baena Ana, Giraldo Margarita, Norton Dan, Cronin-Golomb Alice, Arboleda-Velasquez Joseph F, Quiroz Yakeel T, Miller John B
Abstract excerpt
Importance: Individuals with autosomal dominant mutations for Alzheimer disease are valuable in determining biomarkers present prior to the onset of cognitive decline, improving the ability to diagnose Alzheimer disease as early as possible. Optical coherence tomography (OCT) has surfaced as a potential noninvasive technique capable of analyzing central nervous system tissues for biomarkers of Alzheimer disease....
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