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Article

Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts.

Biogerontology - 1 Apr 2009

Sejersen Henrik, Rattan Suresh I S

Abstract excerpt

Dicarbonyls glyoxal (GO) and methylglyoxal (MGO) produced during the autoxidation of reducing sugars are a source of macromolecular damage in cells. Since an accumulation of damaged macromolecules is a universal characteristic of aging, we have tested whether GO and MGO which cause oxidative damage to proteins and other macromolecules can bring about accelerated aging in normal human skin fibroblasts in vitro. A...

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PMID: 18758988
DOI: 10.1007/s10522-008-9172-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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