Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds.

International journal of molecular sciences - 30 Dec 2020

Ceccatelli Berti Camilla, Gilea Alexandru Ionut, De Gregorio Marco Armando, Goffrini Paola

Abstract excerpt

Mutations in the pantothenate kinase 2 gene (PANK2) are the cause of pantothenate kinase-associated neurodegeneration (PKAN), the most common form of neurodegeneration with brain iron accumulation. Although different disease models have been created to investigate the pathogenic mechanism of PKAN, the cascade of molecular events resulting from CoA synthesis impairment is not completely understood. Moreover, for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Iron
Share to Lipid Droplets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Metabolism

Share to Lipid Peroxidation

Share to Oxidation-Reduction

Share to Pantothenate Kinase-Associated Neurodegeneration

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 33396642
DOI: 10.3390/ijms22010293
PMCID: PMC7795310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring Yeast as a Study Model of Pantothenate Kinase-Associated Neurodegeneration and for the Identification of Therapeutic Compounds.PMID 33396642Read ↗

Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated NeurodegenerationSemantic proximity Read ↗

Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation.Semantic proximity Read ↗

Redesigning therapies for pantothenate kinase-associated neurodegeneration.Semantic proximity Read ↗

Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration.Semantic proximity Read ↗

Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.Semantic proximity Read ↗

Atypical Pantothenate Kinase-Associated Neurodegeneration with Variable Phenotypes in an Egyptian FamilySemantic proximity Read ↗

Alpha-Lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levelsSemantic proximity Read ↗

Therapeutic approach with commercial supplements for pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels.Semantic proximity Read ↗

Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model.Semantic proximity Read ↗

Down Regulation Of The Expression Of Mitochondrial Phosphopantetheinyl-Proteins In Pantothenate Kinase-Associated Neurodegeneration: Pathophysiological Consequences and Therapeutic PerspectivesSemantic proximity Read ↗

Contribution of Yeast Models to Neurodegeneration ResearchSemantic proximity Read ↗

Acanthocytosis and the c.680 A>G Mutation in the PANK2 Gene: A Study Enrolling a Cohort of PKAN Patients from the Dominican Republic.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.