Article
Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Rana Anil, Seinen Erwin, Siudeja Katarzyna, Muntendam Remco, Srinivasan Balaji, van der Want Johannes J, Hayflick Susan, Reijngoud Dirk-Jan, Kayser Oliver, Sibon Ody C M
Abstract excerpt
Pantothenate kinase-associated neurodegeneration (PKAN), a progressive neurodegenerative disorder, is associated with impairment of pantothenate kinase function. Pantothenate kinase is the first enzyme required for de novo synthesis of CoA, an essential metabolic cofactor. The pathophysiology of PKAN is not understood, and there is no cure to halt or reverse the symptoms of this devastating disease. Recently, we...
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