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Cognition in Schizophrenia: Modeling the Interplay between Interleukin-1β C-511T Polymorphism, Metabolic Syndrome, and Sex.

Neuropsychobiology - 1 Jan 2021

Bosia Marta, Spangaro Marco, Sapienza Jacopo, Martini Francesca, Civardi Serena, Buonocore Mariachiara, Bechi Margherita, Lorenzi Cristina, Cocchi Federica, Bianchi Laura, Guglielmino Carmelo, Cavallaro Roberto

Abstract excerpt

INTRODUCTION: Cognitive deficits and metabolic disturbances are among the main determinants of functional impairment and reduced life expectancy in patients with schizophrenia, and they may share underlying biological mechanisms. Among these, interleukin-1β (IL-1β), a key mediator of inflammatory response, is of particular interest. IL-1β C-511T polymorphism has been associated with neuropsychiatric conditions...

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PMID: 33395686
DOI: 10.1159/000512082

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