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Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes generation of the whole lung

2022-11-02

Abstract excerpt

Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ transplants. Identifying the crucial lineage and the program for lung organogenesis could facilitate designing whole-lung bioengineering. Using lineage-tracing mice and human iPSC-derived lung-directed differentiation, we revealed that gastrulating Foxa2 lineage contributed to both lung mesenchyme and epithelium formation. Inte...

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Literature Corpus work
8f0b3052-1eb7-5420-93a6-7181e1ed15d1
DOI
10.1101/2022.10.31.514628
Open publication

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Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes generation of the whole lungDOI 10.1101/2022.10.31.514628
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