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Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

20 Oct 2023

Abstract excerpt

Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ transplants. Generating the whole organ in conjunction with the thymus is a significant milestone for organ transplantation because the thymus is the central organ to educate immune cells. Using lineage-tracing mice and human pluripotent stem cell (PSC)-derived lung-directed differentiation, we revealed that gastrulating Foxa2...

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PMID: 37861292
DOI: 10.7554/elife.86105

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