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Article

Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice

1 May 2020

Abstract excerpt

The shortage of donor lungs hinders lung transplantation, the only definitive option for patients with end-stage lung disease. Blastocyst complementation enables the generation of transplantable organs from pluripotent stem cells (PSCs) in animal models. Pancreases and kidneys have been generated from PSCs by blastocyst complementation in rodent models. Here, we report the generation of lungs using mouse...

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PMID: 32402288
DOI: 10.1016/j.celrep.2020.107626

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