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Article

Effector Phenotype of Plasmodium falciparum-Specific CD4+ T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations.

The Journal of infectious diseases - 1 Aug 2015

Boyle Michelle J, Jagannathan Prasanna, Bowen Katherine, McIntyre Tara I, Vance Hilary M, Farrington Lila A, Greenhouse Bryan, Nankya Felistas, Rek John, Katureebe Agaba, Arinaitwe Emmanuel, Dorsey Grant, Kamya Moses R, Feeney Margaret E

Abstract excerpt

BACKGROUND: Mechanisms mediating immunity to malaria remain unclear, but animal data and experimental human vaccination models suggest a critical role for CD4(+) T cells. Advances in multiparametric flow cytometry have revealed that the functional quality of pathogen-specific CD4(+) T cells determines immune protection in many infectious models. Little is known about the functional characteristics of...

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PMID: 25646355
DOI: 10.1093/infdis/jiv054
PMCID: PMC4539911

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