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Article

Hierarchical Multivalent Effects Control Influenza Host Specificity

12 Nov 2020

Abstract excerpt

Understanding how emerging influenza viruses recognize host cells is critical in evaluating their zoonotic potential, pathogenicity, and transmissibility between humans. The surface of the influenza virus is covered with hemagglutinin (HA) proteins that can form multiple interactions with sialic acid-terminated glycans on the host cell surface. This multivalent binding affects the selectivity of the virus in ways...

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PMID: 33376792
DOI: 10.1021/acscentsci.0c01175

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