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Article

Association of hOGG1-Cys variants with occurrence of p53 and EGFR deletion mutations in non-small cell lung cancer.

Thoracic cancer - 1 Feb 2021

Chen Ming-Jenn, Shen Ching-Ju, Wang Lee, Chen Po-Ming, Chen Chih-Yi, Lee Huei

Abstract excerpt

BACKGROUND: The human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene encodes a DNA glycosylase that removes 8-hydroxy-2-deoxyguanine (8-OH-dG) DNA damage to protect against gene mutations. The association of hOGG1 Ser326Cys polymorphism with lung cancer risk has predicted that hOGG1-Cys variants are less effective at removing 8-OH-dG damage from DNA; therefore, these variants might show an increased occurrence of...

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Identifiers

PMID: 33372419
DOI: 10.1111/1759-7714.13799
PMCID: PMC7882387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of hOGG1-Cys variants with occurrence of p53 and EGFR deletion mutations in non-small cell lung cancer.PMID 33372419Read ↗

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hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.Semantic proximity Read ↗

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