Article
The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer.
Journal of epidemiology - 1 Jan 2012
Lin Chun-Hsuan, Chen Po-Ming, Cheng Ya-Wen, Chen Chih-Yi, Yuan Chiun-Jye, Lee Huei
Abstract excerpt
BACKGROUND: The hOGG1 Ser326Cys polymorphism is associated with lung cancer risk, but there are limited data regarding an association between the APE1 Asp148Glu polymorphism and lung cancer. Biological evidence shows that the hOGG1-Cys allele results in less DNA repair activity; however, this is not associated with p53 mutation in lung cancer. Therefore, we investigated whether an interaction between hOGG1 and...
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