Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study.

BMC bioinformatics - 28 Dec 2020

Li Jin, Bian Chenyuan, Chen Dandan, Meng Xianglian, Luo Haoran, Liang Hong, Shen Li

Abstract excerpt

BACKGROUND: Although genetic risk factors and network-level neuroimaging abnormalities have shown effects on cognitive performance and brain atrophy in Alzheimer's disease (AD), little is understood about how apolipoprotein E (APOE) ε4 allele, the best-known genetic risk for AD, affect brain connectivity before the onset of symptomatic AD. This study aims to investigate APOE ε4 effects on brain connectivity from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connectome

Share to Diffusion Magnetic Resonance Imaging

Share to Heterozygote

Share to Magnetic Resonance Imaging

Source

Open in PubMed Open full text

Identifiers

PMID: 33371873
DOI: 10.1186/s12859-020-03877-9
PMCID: PMC7768655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study.PMID 33371873Read ↗

Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Semantic proximity Read ↗

Learning Clique Subgraphs in Structural Brain Network Classification with Application to Crystallized CognitionSemantic proximity Read ↗

Apolipoprotein E allele 4 effects on Single-Subject Gray Matter Networks in Mild Cognitive Impairment.Semantic proximity Read ↗

Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele.Semantic proximity Read ↗

Mapping consistent, reproducible, and transcriptionally relevant functional connectome hubs of the human brainSemantic proximity Read ↗

The association between genetic variations and morphology-based brain networks changes in Alzheimer's disease.Semantic proximity Read ↗

Integration of Imaging Genomics Data for the Study of Alzheimer's Disease Using Joint-Connectivity-Based Sparse Nonnegative Matrix FactorizationSemantic proximity Read ↗

Synchronized genetic activities in Alzheimer’s brains revealed by heterogeneity-capturing network analysisSemantic proximity Read ↗

ADAPTIVE TESTING OF SNP-BRAIN FUNCTIONAL CONNECTIVITY ASSOCIATION VIA A MODULAR NETWORK ANALYSIS.Semantic proximity Read ↗

Brain Structure Shapes Function through higher-order Functional InteractionsSemantic proximity Read ↗

Open datasets and code for multi-scale relations on structure, function and neuro-genetics in the human brainSemantic proximity Read ↗

Promises and pitfalls of Topological Data Analysis for brain connectivity analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.