Article
Gene- and pathway-level analyses of iCOGS variants highlight novel signaling pathways underlying familial breast cancer susceptibility.
International journal of cancer - 15 Apr 2021
Lonjou Christine, Eon-Marchais Séverine, Truong Thérèse, Dondon Marie-Gabrielle, Karimi Mojgan, Jiao Yue, Damiola Francesca, Barjhoux Laure, Le Gal Dorothée, Beauvallet Juana, Mebirouk Noura, Cavaciuti Eve, Chiesa Jean, Floquet Anne, Audebert-Bellanger Séverine, Giraud Sophie, Frebourg Thierry, Limacher Jean-Marc, Gladieff Laurence, Mortemousque Isabelle, Dreyfus Hélène, Lejeune-Dumoulin Sophie, Lasset Christine, Venat-Bouvet Laurence, Bignon Yves-Jean, Pujol Pascal, Maugard Christine M, Luporsi Elisabeth, Bonadona Valérie, Noguès Catherine, Berthet Pascaline, Delnatte Capucine, Gesta Paul, Lortholary Alain, Faivre Laurence, Buecher Bruno, Caron Olivier, Gauthier-Villars Marion, Coupier Isabelle, Mazoyer Sylvie, Monraz Luis-Cristobal, Kondratova Maria, Kuperstein Inna, Guénel Pascal, Barillot Emmanuel, Stoppa-Lyonnet Dominique, Andrieu Nadine, Lesueur Fabienne
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) in over 180 loci have been associated with breast cancer (BC) through genome-wide association studies involving mostly unselected population-based case-control series. Some of them modify BC risk of women carrying a BRCA1 or BRCA2 (BRCA1/2) mutation and may also explain BC risk variability in BC-prone families with no BRCA1/2 mutation. Here, we assessed the contribution of...
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