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Article

Analysis of Eya1 and Tbx1 mutants highlights interactions between the muscle and developing cartilage during external ear formation.

Development (Cambridge, England) - 1 Feb 2026

Fons Juan M, Sun Ying, Khonsari Roman H, Tucker Abigail S

Abstract excerpt

Microtia is a common feature of several human syndromes affecting the external ear (pinna), yet the cellular and molecular mechanisms remain poorly understood. Using human embryos and mouse models of branchio-oto-renal (BOR) and 22q11.2 deletion syndromes, we show that the syndromic genes Eya1 and Tbx1 are expressed in mesoderm-derived auricular muscle. In Eya1 mutant mice, auricular muscles failed to form and...

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Share to Bone Morphogenetic Protein 4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cartilage

Share to Fibroblast Growth Factors

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Source

Identifiers

PMID: 41649345
DOI: 10.1242/dev.204784

Genes

BMP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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