Article
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jul 2012
Geng Ruishuang, Melki Sami, Chen Daniel H-C, Tian Guilian, Furness David N, Oshima-Takago Tomoko, Neef Jakob, Moser Tobias, Askew Charles, Horwitz Geoff, Holt Jeffrey R, Imanishi Yoshikazu, Alagramam Kumar N
Abstract excerpt
Mutation in the clarin-1 gene (Clrn1) results in loss of hearing and vision in humans (Usher syndrome III), but the role of clarin-1 in the sensory hair cells is unknown. Clarin-1 is predicted to be a four transmembrane domain protein similar to members of the tetraspanin family. Mice carrying null mutation in the clarin-1 gene (Clrn1(-/-)) show loss of hair cell function and a possible defect in ribbon synapse....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.