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Article

Kindlin3-Dependent CD11b/CD18-Integrin Activation Is Required for Potentiation of Neutrophil Cytotoxicity by CD47-SIRPα Checkpoint Disruption.

Cancer immunology research - 1 Feb 2021

Bouti Panagiota, Zhao Xi Wen, Verkuijlen Paul J J H, Tool Anton T J, van Houdt Michel, Köker Nezihe, Köker Mustafa Yavuz, Keskin Ozlem, Akbayram Sinan, van Bruggen Robin, Kuijpers Taco W, Matlung Hanke L, van den Berg Timo K

Abstract excerpt

The CD47-signal regulatory protein-alpha (SIRPα) immune checkpoint constitutes a therapeutic target in cancer, and initial clinical studies using inhibitors of CD47-SIRPα interactions in combination with tumor-targeting antibodies show promising results. Blockade of CD47-SIRPα interaction can promote neutrophil antibody-dependent cellular cytotoxicity (ADCC) toward antibody-opsonized targets. Neutrophils induce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33355195
DOI: 10.1158/2326-6066.CIR-20-0491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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