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Article

Zebrafish as an in vivo screening tool to establish PARP inhibitor efficacy.

DNA repair - 1 Jan 2021

Vierstraete Jeroen, Fieuws Charlotte, Willaert Andy, Vral Anne, Claes Kathleen Bertha Michaël

Abstract excerpt

Double strand break (DSB) repair through Homologous Recombination (HR) is essential in maintaining genomic stability of the cell. Mutations in the HR pathway confer an increased risk for breast, ovarian, pancreatic and prostate cancer. PARP inhibitors (PARPi) are compounds that specifically target tumours deficient in HR. Novel PARPi are constantly being developed, but research is still heavily focussed on in...

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Identifiers

PMID: 33341473
DOI: 10.1016/j.dnarep.2020.103023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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