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Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status

2 Jul 2020

Abstract excerpt

Poly (ADP-ribose) polymerase (PARP) inhibition in BRCA-mutated cells results in an incapacity to repair DNA damage, leading to cell death caused by synthetic lethality. Within the treatment options for advanced triple negative breast cancer, the PARP inhibitor olaparib is only given to patients with BRCA1/2 mutations. However, these patients may show resistance to this drug and BRCA1/2 wild-type tumors can show a...

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PMID: 32630796
DOI: 10.3390/cancers12071769

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