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FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells

22 Dec 2020

Abstract excerpt

Abstract Human mesenchymal stem/stromal cells (hMSCs) have garnered enormous interest as a potential resource for cell-based therapies. However, the molecular mechanisms regulating senescence in hMSCs remain unclear. To elucidate these mechanisms, we performed gene expression profiling to compare clonal immature MSCs exhibiting multipotency with less potent MSCs. We found that the transcription factor Frizzled 5...

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PMID: 33338299
DOI: 10.1002/stem.3317

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