Article
A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population.
BMC medical genetics - 17 Dec 2020
Seo Jung Yeon, Shin Joong-Gon, Youn Byeong Ju, Namgoong Suhg, Cheong Hyun Sub, Kim Lyoung Hyo, Kim Ji On, Shin Hyoung Doo, Kim Yoon Jun
Abstract excerpt
BACKGROUND: Hepatitis B is known to cause several forms of liver diseases including chronic hepatitis B (CHB), and hepatocellular carcinoma. Previous genome-wide association study of CHB risk has demonstrated that rs12614 of complement factor B (CFB) was significantly associated with CHB risk. In this study, fine-mapping study of previously reported GWAS single nucleotide polymorphism (SNP; CFB rs12614) was...
Topics
- Adult
- Case-Control Studies
- Complement Factor B
- Exons
- Gene Expression