Article
Advancing the understanding and treatment of lung pathologies associated with alpha 1 antitrypsin deficiency.
Therapeutic advances in respiratory disease - 1 Jan 2025
Turner Alice M, Ficker Joachim H, Vianello Andrea, Clarenbach Christian F, Janciauskiene Sabina, Chorostowska-Wynimko Joanna, Stolk Jan, McElvaney Noel Gerard
Abstract excerpt
Alpha 1 antitrypsin deficiency (AATD) is a genetic disorder that alters the functionality and/or serum levels of alpha 1 antitrypsin (AAT). Dysfunctional forms of AAT, or low levels of serum AAT, predispose affected individuals to pulmonary complications. When AATD-associated lung disease develops, the most common pulmonary pathology is emphysema. The development of emphysema and decline in lung function varies...
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