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Transcription Strikes Back: Clinical Utility of Lung Adenocarcinoma Subtypes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2021

Skoulidis Ferdinandos

Abstract excerpt

Using transcriptional profiling, three robust subtypes of nonsquamous non-small cell lung cancer were defined, independently of initiating oncogenic driver events. Subtype-specific differential sensitivity to MEK1/2 inhibitors was reported and an interaction between the mucinous subtype, STK11/LKB1 genomic alterations, and inferior clinical outcomes with atezolizumab in the OAK clinical trial was identified.See...

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PMID: 33328344
DOI: 10.1158/1078-0432.CCR-20-3914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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