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Article

RNA sequencing identifies lung cancer lineage and facilitates drug repositioning.

PeerJ - 1 Jan 2024

Zeng Longjin, Zhang Longyao, Li Lingchen, Liao Xingyun, Yin Chenrui, Zhang Lincheng, Chen Xiewan, Sun Jianguo

Abstract excerpt

Recent breakthrough therapies have improved survival rates in non-small cell lung cancer (NSCLC), but a paradigm for prospective confirmation is still lacking. Patientdatasets were mainly downloaded from TCGA, CPTAC and GEO. We conducted downstream analysis by collecting metagenes and generated 42-gene subtype classifiers to elucidate biological pathways. Subsequently, scRNA, eRNA, methylation, mutation, and copy...

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Share to Antineoplastic Agents
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Repositioning

Share to Lung Neoplasms

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Share to Sequence Analysis, RNA

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Source

Open in PubMed Open full text

Identifiers

PMID: 39346064
DOI: 10.7717/peerj.18159
PMCID: PMC11430167

Genes

CCK
KLF5
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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