Article
Three-Dimensional Cell Culture Models to Investigate Oral Carcinogenesis: A Scoping Review
14 Dec 2020
Abstract excerpt
Three-dimensional (3-D) cell culture models, such as spheroids, organoids, and organotypic cultures, are more physiologically representative of the human tumor microenvironment (TME) than traditional two-dimensional (2-D) cell culture models. They have been used as in vitro models to investigate various aspects of oral cancer but, to date, have not be widely used in investigations of the process of oral...
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