Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1.

doi:10.1007/s00401-020-02247-2

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Article

Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1.

Acta neuropathologica - 1 Feb 2021

Sievers Philipp, Sill Martin, Blume Christina, Tauziede-Espariat Arnault, Schrimpf Daniel, Stichel Damian, Reuss David E, Dogan Helin, Hartmann Christian, Mawrin Christian, Hasselblatt Martin, Stummer Walter, Schick Uta, Hench Jürgen, Frank Stephan, Ketter Ralf, Schweizer Leonille, Schittenhelm Jens, Puget Stéphanie, Brandner Sebastian, Jaunmuktane Zane, Küsters Benno, Abdullaev Zied, Pekmezci Melike, Snuderl Matija, Ratliff Miriam, Herold-Mende Christel, Unterberg Andreas, Aldape Kenneth, Ellison David W, Wesseling Pieter, Reifenberger Guido, Wick Wolfgang, Perry Arie, Varlet Pascale, Pfister Stefan M, Jones David T W, von Deimling Andreas, Sahm Felix

Abstract excerpt

Clear cell meningioma represents an uncommon variant of meningioma that typically affects children and young adults. Although an enrichment of loss-of-function mutations in the SMARCE1 gene has been reported for this subtype, comprehensive molecular investigations are lacking. Here we describe a molecularly distinct subset of tumors (n = 31), initially identified through genome-wide DNA methylation screening...

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Identifiers

PMID: 33319313
DOI: 10.1007/s00401-020-02247-2
PMCID: PMC7847462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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