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Article

Transcriptional response modules characterize IL-1β and IL-6 activity in COVID-19

7 Dec 2020

Abstract excerpt

Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines in vivo are urgently needed to complement clinical trials of therapeutic targeting of IL-1β and IL-6 in COVID-19. We show that the expression of IL-1β or IL-6 inducible transcriptional signatures (modules)...

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PMID: 33319166
DOI: 10.1016/j.isci.2020.101896

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