Article
Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL.
Leukemia - 1 Oct 2020
Baliñas-Gavira Carlos, Rodríguez María I, Andrades Alvaro, Cuadros Marta, Álvarez-Pérez Juan Carlos, Álvarez-Prado Ángel F, de Yébenes Virginia G, Sánchez-Hernández Sabina, Fernández-Vigo Elvira, Muñoz Javier, Martín Francisco, Ramiro Almudena R, Martínez-Climent José A, Medina Pedro P
Abstract excerpt
Mutations in genes encoding subunits of the SWI/SNF chromatin remodeling complex are frequently found in different human cancers. While the tumor suppressor function of this complex is widely established in solid tumors, its role in hematologic malignancies is largely unknown. Recurrent point mutations in BCL7A gene, encoding a subunit of the SWI/SNF complex, have been reported in diffuse large B-cell lymphoma...
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