Article
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection.
Emerging microbes & infections - 1 Dec 2021
Wang Shao-Juan, Chen Zi-Min, Wei Min, Liu Jia-Qi, Li Zong-Lin, Shi Tian-Shu, Nian Sheng, Fu Rao, Wu Yang-Tao, Zhang Ya-Li, Wang Ying-Bin, Zhang Tian-Ying, Zhang Jun, Xiong Jun-Hui, Tong Shu-Ping, Ge Sheng-Xiang, Yuan Quan, Xia Ning-Shao
Abstract excerpt
Hepatitis B e antigen (HBeAg) is a widely used marker both for chronic hepatitis B (CHB) clinical management and HBV-related basic research. However, due to its high amino acid sequence homology to hepatitis B core antigen (HBcAg), most of available anti-HBe antibodies are cross-reactive with HBcAg resulting in high interference against accurate measurement of the status and level of HBeAg. In the study, we...
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