Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common copy-number breakpoint of ERBB2 amplification in breast cancer colocalizes with a complex block of segmental duplications.

Breast cancer research : BCR - 26 Nov 2012

Marotta Michael, Chen Xiongfong, Inoshita Ayako, Stephens Robert, Budd G Thomas, Crowe Joseph P, Lyons Joanne, Kondratova Anna, Tubbs Raymond, Tanaka Hisashi

Abstract excerpt

INTRODUCTION: Segmental duplications (low-copy repeats) are the recently duplicated genomic segments in the human genome that display nearly identical (> 90%) sequences and account for about 5% of euchromatic regions. In germline, duplicated segments mediate nonallelic homologous recombination and thus cause both non-disease-causing copy-number variants and genomic disorders. To what extent duplicated segments...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Breakpoints
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to DNA Copy Number Variations

Share to Gene Amplification

Share to Gene Dosage

Share to Receptor, ErbB-2

Share to Segmental Duplications, Genomic

Source

Open in PubMed Open full text

Identifiers

PMID: 23181561
DOI: 10.1186/bcr3362
PMCID: PMC4053137

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common copy-number breakpoint of ERBB2 amplification in breast cancer colocalizes with a complex block of segmental duplications.PMID 23181561Read ↗

The fragility of a structurally diverse duplication block triggers recurrent genomic amplification.Semantic proximity Read ↗

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.Semantic proximity Read ↗

Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution.Semantic proximity Read ↗

Complex rearrangements fuel ER+ and HER2+ breast tumoursSemantic proximity Read ↗

High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization.Semantic proximity Read ↗

Whole-Genome analyses of 1,364 breast cancers with clinical recordsSemantic proximity Read ↗

Segmental duplications and copy-number variation in the human genome.Semantic proximity Read ↗

DNA breakpoint assay reveals a majority of gross duplications occur in tandem reducing VUS classifications in breast cancer predisposition genes.Semantic proximity Read ↗

Remarkable similarities of chromosomal rearrangements between primary human breast cancers and matched distant metastases as revealed by whole-genome sequencingSemantic proximity Read ↗

Linkage disequilibrium and heritability of copy-number polymorphisms within duplicated regions of the human genome.Semantic proximity Read ↗

Complex rearrangements and oncogene amplifications revealed by long-read DNA and RNA sequencing of a breast cancer cell lineSemantic proximity Read ↗

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.