The T-182C Polymorphism Enhances Promoter Activity of the Norepinephrine Transporter Gene, but may not be Associated with Antidepressant Response.

doi:10.1089/gtmb.2020.0092

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The T-182C Polymorphism Enhances Promoter Activity of the Norepinephrine Transporter Gene, but may not be Associated with Antidepressant Response.

Genetic testing and molecular biomarkers - 1 Dec 2020

Zhao Xiaofeng, Cui Wenhui, Liu Qian, Cao Suxia, Pang Jianyue, Li Hengfen

Abstract excerpt

Background: Previous evidence has suggested that norepinephrine transporter (NET) gene (solute carrier family 6, member 2 [SLC6A2]) polymorphisms are involved in antidepressant response. Specifically, the polymorphism T-182C (rs2242446) located in the promoter region of SLC6A2 has been found to be associated with antidepressant response in multiple ethnic backgrounds. However, the results are inconsistent....

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PMID: 33290143
DOI: 10.1089/gtmb.2020.0092

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