Article
Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2002
Zill Peter, Engel Rolf, Baghai Thomas C, Juckel Georg, Frodl Thomas, Müller-Siecheneder Florian, Zwanzger Peter, Schüle Cornelius, Minov Christo, Behrens Stefanie, Rupprecht Rainer, Hegerl Ulrich, Möller Hans Jürgen, Bondy Brigitta
Abstract excerpt
Disturbances in the noradrenergic neurotransmission system have been implicated in the etiology of mood disorders. The norepinephrine transporter (NET) is a main target of antidepressant action and was shown to be dysregulated in major depression. Despite the clinical and physiological significance of NET gene regulation, little is known about the transcriptional control mechanisms governing its expression. Since...
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