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Article

Large-scale genomic analysis reveals significant role of insertion sequences in antimicrobial resistance of Acinetobacter baumannii.

mBio - 12 Mar 2025

Xie Fei, Wang Lifeng, Li Song, Hu Long, Wen Yanhua, Li Xuming, Ye Kun, Duan Zhimei, Wang Qi, Guan Yuanlin, Zhang Ye, Shi Qiqi, Yang Jiyong, Xia Han, Xie Lixin

Abstract excerpt

Acinetobacter baumannii, a prominent nosocomial pathogen renowned for its extensive resistance to antimicrobial agents, poses a significant challenge in the accurate prediction of antimicrobial resistance (AMR) from genomic data. Despite thorough researches on the molecular mechanisms of AMR, gaps remain in our understanding of key contributors. This study utilized rule-based and three machine learning models to...

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Identifiers

PMID: 39976435
DOI: 10.1128/mbio.02852-24
PMCID: PMC11898611

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