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Article

Unveiling molecular associations of polymorphic variants of VDR gene (FokI, BsmI and ApaI) in multiple myeloma patients of Indian population.

The Journal of steroid biochemistry and molecular biology - 1 May 2020

Kumar Raman, Himani, Gupta Nidhi, Singh Vishwajeet, Kumar Vimal, Haq Afrozul, Mirza Anissa Atif, Sharma Alpana

Abstract excerpt

Multiple myeloma (MM) is a plasma cell malignancy frequently accompanied with skeletal co-morbidity. Vitamin D (1,25(OH)2D) is an important mediator of skeletal homeostasis that mediates its effect by binding to vitamin D receptor (VDR), a steroid family receptor and modulates various downstream pathways. Multiple polymorphisms have been determined in VDR gene that witnessed significant association with cancer...

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PMID: 32004705
DOI: 10.1016/j.jsbmb.2020.105588

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