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Article

The combinatorial diversity of KIR and HLA class I allotypes in Peninsular Malaysia.

Immunology - 1 Apr 2021

Tao Sudan, Kichula Katherine M, Harrison Genelle F, Farias Ticiana Della Justina, Palmer William H, Leaton Laura Ann, Hajar Che Ghazali Norul, Zefarina Zulkafli, Edinur Hisham Atan, Zhu Faming, Norman Paul J

Abstract excerpt

Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allelic polymorphism within individuals and across geographical populations. To analyse currently...

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Identifiers

PMID: 33283280
DOI: 10.1111/imm.13289
PMCID: PMC7968402

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