Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia.

EBioMedicine - 1 Dec 2020

Wada Yuina, Maekawa Motoko, Ohnishi Tetsuo, Balan Shabeesh, Matsuoka Shigeru, Iwamoto Kazuya, Iwayama Yoshimi, Ohba Hisako, Watanabe Akiko, Hisano Yasuko, Nozaki Yayoi, Toyota Tomoko, Shimogori Tomomi, Itokawa Masanari, Kobayashi Tetsuyuki, Yoshikawa Takeo

Abstract excerpt

BACKGROUND: The pathophysiology of schizophrenia, a major psychiatric disorder, remains elusive. In this study, the role of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) families, belonging to the ligand-activated nuclear receptor superfamily, in schizophrenia, was analyzed. METHODS: The PPAR/RXR family genes were screened by exploiting molecular inversion probe (MIP)-based targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to PPAR alpha

Share to Protein Conformation

Share to Retinoid X Receptors

Share to Schizophrenia

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 33279456
DOI: 10.1016/j.ebiom.2020.103130
PMCID: PMC7728824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia.PMID 33279456Read ↗

Variants and expression changes in PPAR-encoding genes display no significant association with schizophrenia.Semantic proximity Read ↗

Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-α gene (PPARA) and schizophrenia.Semantic proximity Read ↗

Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genesSemantic proximity Read ↗

Transcriptomic Analysis Shows Decreased Cortical Expression of NR4A1, NR4A2 and RXRB in Schizophrenia and Provides Evidence for Nuclear Receptor Dysregulation.Semantic proximity Read ↗

CPT2-Linked Fatty Acid Oxidation and Autophagy Nodes Connect NMN-Responsive Transcriptional Programs to Schizophrenia BiologySemantic proximity Read ↗

An association between the PPARα-L162V polymorphism and nicotine dependency among patients with schizophrenia.Semantic proximity Read ↗

Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence.Semantic proximity Read ↗

Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study.Semantic proximity Read ↗

The neurobiology of schizophrenia: new leads and avenues for treatment.Semantic proximity Read ↗

Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association StudySemantic proximity Read ↗

Gender differences in the effects of peroxisome proliferator-activated receptor γ2 gene polymorphisms on metabolic adversity in patients with schizophrenia or schizoaffective disorder.Semantic proximity Read ↗

The role of the retinoids in schizophrenia: genomic and clinical perspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.