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Article

Mice with an RGS-insensitive Gαi2 protein show growth hormone axis dysfunction.

Molecular and cellular endocrinology - 5 Feb 2021

Omouessi S Thierry, Leipprandt Jeffrey R, Akoume Marie-Yvonne, Charbeneau Raelene, Wade Susan, Neubig Richard R

Abstract excerpt

Mice carrying an RGS-insensitive Gαi2 mutation display growth retardation early after birth. Although the growth hormone (GH)-axis is a key endocrine modulator of postnatal growth, its functional state in these mice has not been characterized. The present study was undertaken to address this issue. Results revealed that pituitary mRNA levels for GH, prolactin (PRL), somatostatin (SST), GH-releasing-hormone...

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Source

Identifiers

PMID: 33278490
DOI: 10.1016/j.mce.2020.111098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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