Article
Functional brain imaging in glucocerebrosidase mutation carriers with and without parkinsonism.
Movement disorders : official journal of the Movement Disorder Society - 15 Sept 2010
Kono Satoshi, Ouchi Yasuomi, Terada Tatsuhiro, Ida Hiroyuki, Suzuki Makiko, Miyajima Hiroaki
Abstract excerpt
Mutations in the glucocerebrosidase gene (GBA) increase the risk for Parkinson's disease and are also associated with an earlier onset of the disease and an akinetic parkinsonian phenotype. To investigate the underlying pathogenesis of this condition, we assessed cerebral metabolism using positron emission tomography (PET) in GBA mutation carriers with and without parkinsonism. [(18)F]-fluorodeoxyglucose...
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