Article
Engineering CGTase to improve synthesis of alkyl glycosides.
Glycobiology - 3 Jun 2021
Ara Kazi Zubaida Gulshan, Linares-Pastén Javier A, Jönsson Jonas, Viloria-Cols Maria, Ulvenlund Stefan, Adlercreutz Patrick, Karlsson Eva Nordberg
Abstract excerpt
Alkyl glycoside surfactants with elongated carbohydrate chains are useful in different applications due to their improved biocompatibility. Cyclodextrin glucanotransferases can catalyze the elongation process through the coupling reaction. However, due to the presence of a hydrophobic tail, the interaction between an alkyl glycoside acceptor and the active site residues is weaker than the interaction with...
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