Effects of temperature inactivation of penicillin-binding protein 2 on envelope growth in Escherichia coli.

doi:10.1016/0769-2609(87)90039-1

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Article

Effects of temperature inactivation of penicillin-binding protein 2 on envelope growth in Escherichia coli.

Annales de l'Institut Pasteur. Microbiology - 1 Jan 2000

Buchnik D, Woldringh C L, Zaritsky A

Abstract excerpt

The transition from rod-shaped to spheroidal cells was studied in a temperature-sensitive strain (SP45) of Escherichia coli K12, carrying a mutation (pbpA) in the gene coding for penicillin-binding protein 2 (PBP-2). This transition imposed by the restrictive temperature was associated with reduction of peptidoglycan/surface area and of cellular osmotic stability. Addition of nalidixic acid (20 micrograms/ml) at...

Topics

Acyltransferases
Bacterial Proteins
Carrier Proteins
Cell Division
Cell Wall
Escherichia coli
Hexosyltransferases
Microscopy, Electron
Multienzyme Complexes
Muramoylpentapeptide Carboxypeptidase
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nalidixic Acid

Osmotic Fragility

Penicillin-Binding Proteins

Peptidoglycan

Peptidyl Transferases

Temperature

Source

Open in PubMed

Identifiers

PMID: 3326629
DOI: 10.1016/0769-2609(87)90039-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3326629-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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