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Article

Overproduction of penicillin-binding protein 2 and its inactive variants causes morphological changes and lysis in Escherichia coli.

Journal of bacteriology - 1 Jul 2007

Legaree Blaine A, Adams Calvin B, Clarke Anthony J

Abstract excerpt

Penicillin-binding protein 2 (PBP 2) has long been known to be essential for rod-shaped morphology in gram-negative bacteria, including Escherichia coli and Pseudomonas aeruginosa. In the course of earlier studies with P. aeruginosa PBP 2, we observed that E. coli was sensitive to the overexpression of its gene, pbpA. In this study, we examined E. coli overproducing both P. aeruginosa and E. coli PBP 2. Growth of...

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Identifiers

PMID: 17513478
DOI: 10.1128/JB.00207-07
PMCID: PMC1951868

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Source receipt: pubmed, retrieved 7 Sept 2026.

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