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Article

FAHFAs Regulate the Proliferation of C2C12 Myoblasts and Induce a Shift toward a More Oxidative Phenotype in Mouse Skeletal Muscle.

International journal of molecular sciences - 28 Nov 2020

Benlebna Melha, Balas Laurence, Pessemesse Laurence, Bonafos Béatrice, Fouret Gilles, Pavlin Laura, Goustard Bénédicte, Gaillet Sylvie, Durand Thierry, Coudray Charles, Feillet-Coudray Christine, Casas François

Abstract excerpt

Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids reported to have antidiabetic and anti-inflammatory effects. Since skeletal muscle is a major target for insulin, the aim of this study is to explore for the first time the influence of several FAHFAs in C2C12 myoblasts and in skeletal muscle phenotype in mice. Here, we show that eleven FAHFAs belonging to different families inhibit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33260741
DOI: 10.3390/ijms21239046
PMCID: PMC7729663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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