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Article

An in silico approach to analyze HCV genotype-specific binding-site variation and its effect on drug-protein interaction.

Scientific reports - 30 Nov 2020

Khalid Ramsha, Anwar Muhammad Faraz, Raees Muhammad Aanish, Naeem Sadaf, Abidi Syed Hani, Ali Syed

Abstract excerpt

Genotype variation in viruses can affect the response of antiviral treatment. Several studies have established approaches to determine genotype-specific variations; however, analyses to determine the effect of these variations on drug-protein interactions remain unraveled. We present an in-silico approach to explore genotype-specific variations and their effect on drug-protein interaction. We have used HCV NS3...

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Source

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Identifiers

PMID: 33257748
DOI: 10.1038/s41598-020-77720-9
PMCID: PMC7705671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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