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Article

Sphingolipid-Containing Outer Membrane Vesicles Serve as a Delivery Vehicle To Limit Macrophage Immune Response to Porphyromonas gingivalis.

Infection and immunity - 17 Mar 2021

Rocha Fernanda G, Ottenberg Gregory, Eure Zavier G, Davey Mary E, Gibson Frank C

Abstract excerpt

Sphingolipids (SLs) are essential structural components of mammalian cell membranes. Our group recently determined that the oral anaerobe Porphyromonas gingivalis delivers its SLs to host cells and that the ability of P. gingivalis to synthesize SLs limits the elicited host inflammatory response during cellular infection. As P. gingivalis robustly produces outer membrane vesicles (OMVs), we hypothesized that OMVs...

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Identifiers

PMID: 33361202
DOI: 10.1128/IAI.00614-20
PMCID: PMC8090959

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