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Article

Integrative genomic meta-analysis reveals novel molecular insights into cystic fibrosis and ΔF508-CFTR rescue.

Scientific reports - 25 Nov 2020

Hodos Rachel A, Strub Matthew D, Ramachandran Shyam, Li Li, McCray Paul B, Dudley Joel T

Abstract excerpt

Cystic fibrosis (CF), caused by mutations to CFTR, leads to severe and progressive lung disease. The most common mutant, ΔF508-CFTR, undergoes proteasomal degradation, extinguishing its anion channel function. Numerous in vitro interventions have been identified to partially rescue ΔF508-CFTR function yet remain poorly understood. Improved understanding of both the altered state of CF cells and the mechanisms of...

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Identifiers

PMID: 33239626
DOI: 10.1038/s41598-020-76347-0
PMCID: PMC7689470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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