Article
A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function.
American journal of respiratory cell and molecular biology - 1 Sept 2014
Ramachandran Shyam, Osterhaus Samantha R, Karp Philip H, Welsh Michael J, McCray Paul B
Abstract excerpt
The most common cystic fibrosis (CF) mutation, ΔF508, causes protein misfolding, leading to proteosomal degradation. We recently showed that expression of miR-138 enhances CF transmembrane conductance regulator (CFTR) biogenesis and partially rescues ΔF508-CFTR function in CF airway epithelia. We hypothesized that a genomic signature approach can be used to identify new bioactive small molecules affecting...
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